Delivery system comprising means for controlling internal pressure
AssigneeAlza Corporation
InventorsJeremy C. Wright, James B. Eckenhoff, Frederick H. Maruyama, John R. Peery
Life of this patent
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Abstract
The present invention is directed to an improvement in a delivery system, the system comprising a wall that surrounds an internal lumen or compartment which contains a thermo-responsive beneficial agent formulation, an expandable driving member and an optional density member, and having an exit opening, and wherein the improvement comprises a) a viscosity-inducing amount of an inert viscosity-inducing agent in the thermo-responsive beneficial agent composition for increasing the viscosity of the beneficial agent composition, and/or b) a pressure-inducing exit member in the exit opening in the wall for increasing the pressure inside the lumen.
Claims29
An improved delivery system for administering a beneficial agent to an environment of use, the delivery system comprising:
- i) a wall that surrounds a lumen, the wall comprising in at least a part a semipermeable composition,
- ii) a thermo-responsive composition in the lumen that forms a dispensable formulation at the temperature of the environment of use,
- iii) a beneficial agent mixed with the thermo-responsive composition,
- iv) an expandable driving member in the lumen for displacing the thermo-responsive composition from the delivery system, and
- v) an exit opening in the wall that communicates with the lumen;
- wherein, the improvement comprises:
- a) a viscosity-inducing amount of an inert viscosity-inducing agent in the thermo-responsive composition for increasing the viscosity of the thermo-responsive composition, and
- b) a pressure-inducing exit member in the exit opening in the wall for increasing the pressure inside the lumen, the exit member having from 1 to exit ports or passageways;
- wherein the delivery system when in operation develops an internal pressure such that the pressure differential generated by the thermo-responsive composition and the exit member is greater than 1.5 psi.
An improved delivery system for administering a beneficial agent to an environment of use, the delivery system comprising:
- i) a wall that surrounds a lumen,
- ii) a thermo-responsive composition in the lumen,
- iii) a beneficial agent mixed with the thermo-responsive composition,
- iv) an expandable driving member in the lumen for displacing the thermo-responsive composition from the dispenser, and
- v) an exit opening in the wall that communicates with the lumen;
- wherein, the improvement comprises:
- a) a viscosity-inducing amount of an inert viscosity-inducing agent mixed into the thermo-responsive composition for increasing the viscosity of the thermo-responsive composition to increase the internal pressure of the dispenser;
- wherein the delivery system when in operation develops an internal pressure such that the pressure differential generated by the thermo-responsive composition and the exit opening is greater than 1.5 psi.
An improved delivery system for administering a beneficial agent to an environment of use, the delivery system comprising:
- i) a wall that surrounds a lumen,
- ii) a thermo-responsive composition in the lumen,
- iii) a beneficial agent mixed with the thermo-responsive composition,
- iv) an expandable driving member in the lumen for displacing the thermo-responsive composition from the dispenser, and
- v) an exit opening in the wall that communicates with the lumen;
- wherein, the improvement comprises:
- a) a pressure-inducing exit member in the exit opening in the wall for increasing the pressure inside the lumen, the exit member having from 1 to 200 exit ports or passageways;
- wherein the delivery system when in operation develops an internal pressure such that the pressure differential generated by the thermo-responsive composition and the exit member is greater than 1.5 psi.
Dependencies are inferred from the claim text.