Treatment of microbial infection by monocyte stimulation with interleukin-7
AssigneeSterling Winthrop Inc.
InventorsKenneth Grabstein, Mark Alderson
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Abstract
There is disclosed a method of treating microbial infections in microbially infected mammals and a method of augmenting antitumor immunotoxicity in a mammal comprising administering a therapeutically effective amount of IL-7 in a pharmaceutically acceptable carrier. There is further disclosed a method of stimulating macrophages to produce cytokines made by activated macrophages and a method for improving T cell presentation by a macrophage comprising administering a therapeutically effective amount of IL-7. Further, antimicrobial activity of macrophages can be improved by administering a combination of IL-7 and Interferon-.gamma..
Claims16
A method of treating a mammal afflicted with an infectious disease caused by a microbe or group of microbes selected from the group consisting of gram negative bacteria, gram positive bacteria, yeast, fungi, and protozoa, comprising administering an amount of IL-7 effective to activate mononuclear phagocytes in a pharmaceutically acceptable carrier.
A method of treating a mammal afflicted with an infectious disease caused by a microbe or group of microbes selected from the group consisting of gram negative bacteria, gram positive bacteria, yeast, fungi, and protozoa, comprising administering a pharmaceutical composition comprising an amount of an IL-7 and an amount of an IFN-.gamma. each effective to activate mononuclear phagocytes in a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.