Prevention of acetaminophen overdose toxicity with organosulfur compounds
AssigneeRutgers University
InventorChung S. Yang
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Abstract
A method of preventing acetaminophen (APAP)-induced hepatotoxicity utilizing diallyl sulfide (DAS) and diallyl sulfone (DASO.sub.2) is disclosed. DAS and DASO.sub.2 are prepared as an oral dosage form or injected. In a preferred embodiment, diallyl sulfone is added to a dosage form of acetaminophen in an amount effective to prevent the metabolism of said unit dose of acetaminophen into its hepatotoxic metabolites. In certain preferred embodiments, the above formulations further include an effective amount of N-acetylcysteine to detoxify hepatotoxic metabolites of acetaminophen.
Claims25
A method of treating acetaminophen overdose in a patient who has ingested an hepatotoxic dose of acetaminophen, comprising administering a protective agent comprising diallyl sulfone in an amount effective to prevent the metabolism of the ingested dose of acetaminophen into its hepatotoxic metabolites.
A method for treating acetaminophen overdose in a patient who has ingested an hepatotoxic dose of acetaminophen, comprising
- administering a protective agent comprising diallyl sulfone in an effective amount to substantially prevent the cytochrome P-450 2E1 induced metabolism of the ingested dose of acetaminophen to N-acetyl-p-benzoquinone imine.
A method for the treatment of pain or fever with acetaminophen which prevents the formation of hepatotoxic metabolites of acetaminophen in the event that a patient is exposed to an otherwise hepatotoxic overdose of acetaminophen, comprising
- administering to a human as a unit dose a therapeutically effective amount of acetaminophen together with a protective agent comprising diallyl sulfone in an effective amount to substantially inhibit the metabolism of the therapeutically effective amount of acetaminophen into a hepatotoxic metabolite.
An oral dosage form for treating an hepatotoxic overdose of acetaminophen, comprising a pharmaceutically acceptable unit dose of acetaminophen and a protective agent comprising diallyl sulfone in a pharmaceutically acceptable amount effective to prevent the metabolism of at least a portion of an ingested dose of acetaminophen into its hepatotoxic metabolites.
An oral dosage form, comprising
- a pharmaceutically acceptable unit dose of acetaminophen, and
- a protective agent comprising diallyl sulfone in an amount effective to prevent the metabolism of said unit dose of acetaminophen into its hepatotoxic metabolites.
Dependencies are inferred from the claim text.