Tumor associated monoclonal antibodies
AssigneeAkzo Nobel N.V.
InventorsMichael G. Hanna, Jr., Martin V. Haspel, Herbert C. Hoover, Jr., Marie E. Dembinsky, Barry J. Kobrin
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Abstract
This invention relates to monoclonal antibody 88BV59 produced by B-cell lines derived from B-cells of cancer patients actively immunized with autologous tumor antigen. These monoclonal antibodies can be used in both diagnostic procedures and therapy for human cancers.
Claims11
A transformed human lymphocyte cell line designated 88BV59-1, ATCC accession number CRL 10624, and subclones thereof.
A transformed human lymphocyte cell line designated 88BV59H21-2, ATCC accession number CRL 11538, and subclones thereof.
A transformed human lymphocyte cell line designated 88BV59H21-2V67-66, ATCC accession number CRL 11539, and subclones thereof.
A human monoclonal antibody 88BV59, produced by a transformed human lymphocyte cell line selected from the group consisting of ATCC CRL 10624, ATCC CRL 11538, ATCC CRL 11539 and a subclone thereof, or an antigen binding fragment of human monoclonal antibody 88BV59.
Dependencies are inferred from the claim text.