A dripless cannula system usable with a fluid container for fluid sampling and operable to remove residual fluid from a fluid sampling site, said system comprising a blunt cannula comprising an outer blunt cannula receiving an inner cannula therein for reciprocable movement, said blunt cannula having a distal end receivable in a fluid sampling site and a proximal end including structure capable of connecting said cannula to the fluid container and in locking fluid-tight engagement therewith, to provide a fluid path through said inner cannula from said sampling site to said fluid container, a vacuum chamber connected to the outer cannula and disposed about the inner cannula in sealing relationship to prevent fluid flow between the sampling site and the fluid container, said vacuum chamber operable after the sampling process and during withdrawal of the inner cannula from the sampling site to remove residual fluids disposed at the sampling site by the sampling process.