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US 5,474,535 AGranted
Dosage and inserter for treatment of erectile dysfunction
AssigneeVivus, Inc.
InventorsVirgil A. Place, Robert M. Gale, Randall G. Berggren
Life of this patent
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Abstract
Erectile dysfunction, particularly impotence, priapism and Peyronie's disease is treated by the transurethral administration of a therapeutically effective agent. The agents are administered to the urethra by means of a penile insert (40) having a shaft with a deformable distal end which forms a dose receiving cavity when an internal piston is retracted relative to the shaft.
Claims21
A dosage form for treating an erectile dysfunction, said dosage form comprising, in combination:
- a) a shaft having a diameter that is receivable in the male urethra, said shaft having a proximal end and a blunted distal end;
- b) means to prevent complete insertion of said shaft into the urethra on the proximal end of said shaft;
- and
- c) a dose of a therapeutic composition for said erectile dysfunction carried in said shaft prior to insertion in the urethra, said therapeutic composition comprising a therapeutic agent for said erectile dysfunction, wherein said dose weighs less than about 100 mgs, is solid at ambient temperature, and is capable of being dissolved, absorbed, melted or bioeroded in the urethra.
1 more element
A dosage form for treating erectile dysfunction, said dosage form comprising, in combination:
- a) an insert comprising:
- (i) a shaft having a proximal end and a distal end sized to be received within the male urethra;
- and
- (ii) a bore within said shaft;
- b) a piston slidably received within said bore and movable from a first position where said piston forms a dose receiving cavity proximate to the distal end of said shaft to a second position where said dose is displaced from said cavity;
- and
- c) a dose of a therapeutic composition for said erectile dysfunction comprising said therapeutic agent for said erectile dysfunction, said dose being received in said cavity, wherein said dose is solid at ambient temperature, and is capable of being dissolved, absorbed, melted or bioeroded in the urethra.
4 more elements
Dependencies are inferred from the claim text.