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US 5,473,076 AGranted
Enantiomerically pure intermediates for (quinolin-2-yl-methoxy) phenylacetic acids
AssigneeBayer Aktiengesellschaft
InventorsMatthias Decker, Klaus-Helmut Mohrs, Siegfried Raddatz
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Abstract
(Quinolin-2-yl-methoxy)phenylacetic acids are known as inhibitors of enzymatic reactions in the context of arachidonic acid metabolism. Enantiomerically pure (quinolin-2-yl-methoxy)phenylacetic acids can be prepared in a simple manner and in high purity and yield by diastereoselective alkylation of corresponding (quinolin-2-yl-methoxy)phenylacetic acid menthyl esters and subsequent specific removal of the ester radical with acids.
Claims2
A compound of the formula ##STR16## in which A, B, D, E, G and L each independently is hydrogen;
- hydroxyl;
- halogen;
- carboxyl;
- nitro;
- trifluoromethyl;
- trifluoromethoxy;
- straight-chain or branched alkyl or alkoxy each having up to 8 carbon atoms;
- or aryl having 6 to 10 carbon atoms, which is optionally substituted by halogen, hydroxyl, nitro or cyano
- and
- R.sup.2 is a chiral alcohol radical selected from the group consisting of (+)- or (-)-menthyl, (+)- or (-)-bornyl, (+)- or (-)-isobornyl and (+)- or (-)-8-phenylmenthyl.
7 more elements
Dependencies are inferred from the claim text.