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US 5,473,074 AGranted
Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents-54
AssigneeOctamer, Inc.
InventorsErnest Kun, Jerome Mendeleyev
Life of this patent
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Abstract
The subject invention provides for novel compounds for inactivating viruses. These compounds include 6-nitroso-1,2-benzopyrone, 3-nitrosobenzamide, 5-nitroso-1(2H)-isoquinolinone, 7-nitroso-1(2H)-isoquinolinone, 8-nitroso-1(2H)-isoquinolinone. The invention also provides for compositions containing one or more of the compounds, and for methods of treating viral infections, cancer, infectious virus concentration with the subject compounds and compositions.
Claims1
A compound having the formula:
- ##STR4## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are selected from the group consisting of hydrogen and nitroso, and one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 is a nitroso group and the remainder of the R groups are hydrogen.
Dependencies are inferred from the claim text.