Antigen-binding fragments of an antibody to type-I collagen amino-terminal telopeptide
AssigneeWashington Research Foundation
InventorDavid R. Eyre
Life of this patent
Estimating the term…
Abstract
Methods of determining collagen degradation in vivo, by quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a hydroxylysyl pyridinoline cross-link. Suitable methods include immunometric assays, fluorometric assays, and electrochemical titrations for quantitation. The structures of specific peptides having cross-links and kits for quantitating these peptides in a body fluid are described.
Claims1
An antigen-binding fragment of a monoclonal antibody wherein said antibody is produced by a cell having the identifying characteristics of ATCC No. HB 10611, wherein said antigen-binding fragment is isolated L chain of said antibody or is selected from the group consisting of Fab, Facb, F(ab').sub.2, Fab', and Fd fragments of said antibody.
Dependencies are inferred from the claim text.