Polypeptide analogs of apolipoprotein E, diagnostic systems and methods using the analogs
AssigneeThe Scripps Research Institute
InventorsCheryl A. Dyer, Linda K. Curtiss, Richard Smith
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Abstract
The present invention contemplates a multimeric polypeptide capable of mimicking the ability of apo E to induce differentiated cellular function. The repeating unit of the polypeptide has an amino acid residue sequence corresponding to that represented by the formula LRXLRKRLLX. Also contemplated is a method for treating hypercholesterolemia in a patient, which method comprises administering to the patient an LDL plasma concentration-reducing amount of the polypeptide. Described as well, is the use of the polypeptide in preparing diagnostic antibodies, and their use in diagnostic systems and methods for detecting apo E antigens in vascular body fluids.
Claims4
A synthetic polypeptide consisting of two to ten segments each having an amino acid sequence of the formula:
- Leu-Arg-Xaa-Leu-Arg-Lys-Arg-Leu-Leu-Xbb,
- where Xaa is Lys or Ala, and Xbb is Arg or Ala, said polypeptide having the ability to inhibit lymphocyte proliferation.
A synthetic polypeptide consisting of an amino acid sequence corresponding to a formula selected from the group consisting of:
- ##STR2## said polypeptide having the ability to inhibit lymphocyte proliferation.
Dependencies are inferred from the claim text.