Emulsified external treatment composition containing diclofenac sodium
AssigneeShiseido Company, Ltd.
InventorTakashi Suzuki
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Abstract
An emulsified composition for treating the skin containing diclofenac sodium, a fatty acid and a dialkyl carboxylate, as essential components.
Claims5
An emulsified external treatment composition, which comprises, based on the total weight of the composition, (i) an active component consisting essentially of diclofenac sodium, in 0.5 to 5.0%, (ii) 0.5 to 20% of a fatty acid, which is liquid at room temperature, (iii) 0.25 to 50% of a dialkyl carboxylate, the weight ratio of the dialkyl carboxylate to the fatty acid being 1/1 to 5/1, (iv) an oil component, (v) a hydrophilic surfactant and (vi) a humectant.
A process for stably emulsifying diclofenac sodium in an emulsified external treatment composition which comprises:
- a) dissolving under heat 0.5 to 5% by weight of diclofenac sodium in a solution of 0.5 to 20% by weight of a fatty acid which is liquid at room temperature and 0.25 to 50% by weight of dialkyl carboxylate all based upon the total weight of the composition, the weight ratio of the dialkyl carboxylate to the fatty acid being 1/1 to 5/1;
- b) adding to the solution formed in step a), an oil component followed by cooling to produce an oil phase;
- c) forming an aqueous phase by mixing together at least one hydrophilic surfactant and at least one humectant;
- and
- d) emulsifying said oil phase and aqueous phase by adding the oil phase to the aqueous phase under high speed stirring.
Dependencies are inferred from the claim text.