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US 5,472,975 AGranted
Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[b]indoles and related compounds
AssigneeHoechst-Roussel Pharmaceuticals Inc.
InventorsHelen H. Ong, Gerard J. O'Malley, Michael C. Merriman, Mark G. Palermo
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Abstract
There are disclosed various compounds of the formula below, ##STR1## where n, X and R.sub.1 through R.sub.4 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and/or act at central .alpha..sub.2 -adrenergic receptors, and hence are useful as antidepressants.
Claims4
A compound of the formula, ##STR41## where n is 2, 3, 4 or 5;
- X is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, trifluoromethyl or nitro;
- R.sub.1 is loweralkynyl;
- R.sub.2 is hydrogen, loweralkyl, formyl, loweralkylcarbonyl, benzyloxycarbonyl or loweralkylaminocarbonyl;
- R.sub.3 is hydrogen, loweralkyl, arylloweralkyl, loweralkylcarbonyl or loweralkoxycarbonyl;
- R.sub.4 is hydrogen, --OH or ##STR42## wherein R.sub.7 is loweralkyl, aryl or arylloweralkyl;
- or a pharmaceutically acceptable addition salt thereof.
3 more elements
Dependencies are inferred from the claim text.