Fluorenyl derivatives as anti-inflammatory agents

A method of treating an inflammatory condition comprising administering to an animal in need of such treatment an amount of at least one compound represented by the following formula:

• ##STR19## wherein:
• X is selected from the group consisting of methylene, oxygen, ethylene, methyleneoxy, and ethyleneoxy;
• R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, C.sub.1 to C.sub.6 lower alkyl, aryl, aralkyl, alkoxy, alkoxyalkyl, halogen, and nitro;
• R.sub.3 is selected from the group consisting of hydrogen and C.sub.1 to C.sub.6 lower alkyl groups;
• R.sub.4 is selected from the group consisting of -CO.sub.2 H;
• -NHSO.sub.2 R.sub.7, wherein R7 is methyl, or trifluoromethyl;
• -CONHSO.sub.2 R.sub.8, wherein R.sub.8 is methyl, trifluoromethyl, or phenyl;
• 1H-tetrazol-5-yl;
• and -CONH-tetrazol-5-yl;
• R.sub.5 is selected from the group consisting of hydrogen, C.sub.1 to C.sub.6 lower alkyl, halogen, hydroxyl, and a methoxy group;
• and
• R.sub.6 is selected from the group consisting of hydrogen, halogen, C.sub.1 to C.sub.6 lower alkyl, C.sub.1 to C.sub.6 lower alkoxy, C.sub.1 to C.sub.6 lower alkoxy ethers, and alicyclic hydrocarbon groups.

A pharmaceutical composition suitable for use in producing an anti-inflammatory effect in an animal comprising, as an active ingredient, an amount of at least one compound of the following formula administered to an animal together with a pharmaceutically acceptable carrier or diluent ##STR20## wherein:

• X is selected from the group consisting of methylene, oxygen, ethylene, methyleneoxy, and ethyleneoxy;
• R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, C.sub.1 to C.sub.6 lower alkyl, aryl, aralkyl, alkoxy, alkoxyalkyl, halogen, and nitro;
• R.sub.3 is selected from the group consisting of hydrogen, and C.sub.1 to C.sub.6 lower alkyl groups;
• R.sub.4 is selected from the group consisting of -CO.sub.2 H;
• -NHSO.sub.2 R.sub.7, wherein R.sub.7 is methyl, or trifluoromethyl;
• -CONHSO.sub.2 R.sub.8, wherein R.sub.8 is methyl, trifluoromethyl, or phenyl;
• 1H-tetrazol-5-yl;
• and -CONH-tetrazol-5-yl;
• R.sub.5 is selected from the group consisting of hydrogen, C.sub.1 to C.sub.6 lower alkyl, halogen, hydroxyl, and a methoxy group;
• and
• R.sub.6 is selected from the group consisting of hydrogen, halogen, C.sub.1 to C.sub.6 lower alkyl, C.sub.1 to C.sub.6 lower alkoxy, C.sub.1 to C.sub.6 lower alkoxy ethers, and alicyclic hydrocarbo groups.