Fractionated heparin for the therapeutic treatment of malaria
OwnerHans-Peter Ekre, Johan Carlson +4inventors
InventorsHans-Peter Ekre, Johan Carlson, Asli A. Kulane, Peter Perlmann, Mats Wahlgren, Birgitta Wahlin
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Abstract
The invention relates to the use of heparin with low affinity for antithrombin III for the preparation of a medicament in the treatment of malaria. The amount of the heparin with low affinity for antithrombin III could be between 2 and 200 mg in the medicament and the anticoagulant activity is preferably .ltoreq.30 IU/mg as determined by APTT.
Claims12
A method of treating malaria comprising administering to an individual in need of such treatment an effective amount of a medicament containing a heparin fraction having low affinity for antithrombin III, wherein the effective amount of the medicament comprises a daily dosage of the heparin fraction in the range between approximately 0.05 mg/kg of body weight of the individual to approximately 5 mg/kg of body weight of the individual.
A method of treating malaria comprising administering to an individual in need of such treatment an effective amount of a medicament containing a heparin fraction having low affinity for antithrombin III, wherein the effective amount of the medicament comprises a daily dosage of the heparin fraction in the range between approximately 2 mg to approximately 200 mg.
Dependencies are inferred from the claim text.