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AssigneeRichter Gedeon Vegyeszeti Gyar Rt.
InventorsKalman Burger, Ivan Rethey, deceased, Bela Stefko, Istvan Gebhardt, Arpadne Kiraly nee Gyongyver Soos, Geza T. Nagy, Janos Illes, Erzsebet Nesmelyi, Istvan Racz, Viktoria Varkonyi
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Complexes of deprotonated hyaluronic acid with 3d metal ions of the 4th period of the Periodic Table and compositions containing these complexes as active ingredients or carriers. A process for the preparation of the complexes and compositions (pharmaceutical and cosmetic compositions) containing these complexes as active ingredients are disclosed in which zinc or cobalt (II) hyaluronate is preferably used as active ingredient.
A stoichiometric cobalt(II) hyaluronic acid complex prepared through the interaction of equivalent amounts of an alkali metal hyaluronate, alkaline earth metal hyaluronate, silver hyaluronate or quaternary ammonium hyaluronate, and Co(II) ions in aqueous solution wherein the cobalt(II) is surrounded by four oxygen atoms, in the first coordination sphere, the length of the Co--O bond distance is 197 pm.+-.1.0 pm whereas two carbon atoms are present in a longer distance of 239 pm+1.5 pm from the cobalt atom.
A pharmaceutical or cosmetic composition for local administration, which comprises as active ingredient, a pharmaceutically or cosmetically effective amount of a stoichiometric cobalt(II) hyaluronic acid complex prepared through the interaction of equivalent amounts of an alkali metal hyaluronate, alkaline earth metal hyaluronate, silver hyaluronate or quaternary ammonium hyaluronate, and Co(II) ions in aqueous solution wherein the cobalt(II) is surrounded by four oxygen atoms, in the first coordination sphere, the length of the Co--O bond distance is 197 pm.+-.1.0 pm whereas two carbon atoms are present in a longer distance of 239 pm+1.5 pm from the cobalt atom and a pharmaceutically acceptable inert carrier.
Dependencies are inferred from the claim text.