Anti-thrombins
AssigneeBiopharm (UK) Limited
InventorsRoy Sawyer, Christopher Powell-Jones, Anthony Atkinson, Asgar Electricwala
Life of this patent
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Abstract
A polypeptide derived from leeches of the species Hirudinaria manillensis has the following amino acid sequence: ##STR1## wherein Xaa indicates any amino acid residue; D indicates Cys or Pro; E indicates Glu, Asp or His; F indicates Asp, Lys or Trp; or a pharmaceutically acceptable salt, derivative or bioprecursor thereof. The polypeptide, and fragments thereof, is a specific anti-thrombin useful as a medicament.
Claims17
A polypeptide having the following amino acid sequence, SEQ ID NO:4:
- ##STR4## wherein Xaa at positions 1, 2 and 63 is an amino acid residue;
- Xaa at position 30 is Cys or Pro;
- Xaa at position 41 is Glu, Asp or His;
- and Xaa at position 47 is Asp, Lys or Trp.
A polypeptide which specifically inhibits thrombin and which comprises the amino acid sequence:
- ##STR5## wherein Xaa represents an amino acid residue, SEQ ID NO:12.
Dependencies are inferred from the claim text.