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US 5,472,938 AGranted
Pharmaceutical depot compositions containing hirudin
AssigneeCiba-Geigy Corporation
InventorTudor Arvinte
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Abstract
The present invention relates to aqueous depot formulations of hirudin, particularly desulphatohirudin, which are very stable. These formulations contain water, hirudin, and calcium, magnesium, or zinc ions in the form of water insoluble salts, the salts being in a concentration of from 100 mM to 600 mM.
Claims13
An aqueous depot formulation comprising water, hirudin, and metal ions in the form of a water insoluble salt in which the metal is selected from calcium, magnesium, and zinc, the concentration of said salt being from 100 mM to 600 mM.
Dependencies are inferred from the claim text.