Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture

Pharmaceutical preparation to be administered orally, comprising:

• a physiologically safe solid nucleus including at least one pharmacologically active substance;
• an acid layer comprising at least one physiologically safe solid acid over the nucleus;
• and
• a compound membrane over the acid layer, the compound membrane consisting of two discrete layers including a pH sensitive polymer inner layer adjacent the acid layer and an insoluble polymer outer layer adjacent the pH sensitive polymer inner layer, said outer layer being permeable to gastrointestinal secretions.

Pharmaceutical preparation to be administered orally, comprising:

• a physiologically safe solid nucleus;
• the nucleus being enveloped by a layer containing at least one pharmacologically active substance and at least one physiologically safe solid acid;
• and
• a compound membrane over the layer containing the active substance and the physiologically safe acid, the compound membrane consisting of two discrete layers including a pH sensitive polymer inner layer adjacent the acid layer and an insoluble polymer outer layer adjacent the pH sensitive polymer inner layer, said outer layer being permeable to gastrointestinal secretions.

A method of producing a pharmaceutical preparation for oral administration comprising:

• applying a layer containing a pharmacologically active substance onto a physiologically safe nucleus;
• applying a layer of a physiologically safe acid onto the layer of active substance;
• applying a pH sensitive polymer layer to the acid layer;
• and
• applying an insoluble polymer layer to the pH sensitive polymer layer.

A method of producing a pharmaceutical preparation for oral administration comprising:

• preparing a physiologically safe solid nucleus including at least one pharmacologically active substance;
• applying a layer of a physiologically safe solid acid over the nucleus;
• applying a pH sensitive polymer layer to the acid layer;
• and
• applying an insoluble polymer layer to the pH sensitive polymer layer, said insoluble polymer layer being permeable to gastrointestinal secretions.

A method of producing a pharmaceutical preparation for oral administration comprising:

• applying to a physiologically safe solid nucleus a layer containing at least one pharmacologically active substance and at least one physiologically safe solid acid;
• applying a pH sensitive polymer layer to the layer containing the active substance and the safe acid;
• and
• applying an insoluble polymer layer to the pH sensitive polymer layer, said insoluble polymer layer being permeable to gastrointestinal secretions.