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US 5,472,706 AGranted
Dry compositions for preparing submicron emulsions
AssigneePharmos Corporation
InventorsDoron Friedman, Yanir Aldouby
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AssigneePharmos Corporation
InventorsDoron Friedman, Yanir Aldouby
Estimating the term…
The present invention relates to dry, stable compositions which can be reconstituted to form pharmaceutical or cosmetic emulsions, and to methods for making such compositions. An emulsion is formed from about 0.2 to 25 weight percent of a first component of an oil, about 0.1 to 5 weight percent of a second component of an emulsifier, about 0.25 to 25 weight percent of a cryoprotectant of an amino compound, such as one or more amino acids, peptides or protein hydrolysates, and an aqueous component, wherein the amino compound is present in an amount that is equal to or greater than that of the first component. Optionally, a co-emulsifier, a suspension agent, a preservative, an antioxidant and a drug can be added to these emulsions. Thereafter, the emulsion is lyophilized to form dry compositions that have from about 40 to about 90 weight percent of the amino compound; from about 0.1 to about 20 weight percent of the emulsifier; and from about 0.2 to about 40 weight percent of the oily component. By combining the dry composition with an appropriate quantity of an aqueous liquid, the composition is reformed as an oil-in-water emulsion.
A method of making a lyophilized composition which comprises formulating an oil-in-water emulsion comprising water, about 0.2 to 25 weight percent of an oil, about 0.1 to 10 weight percent of an emulsifier, and about 0.25 to 50 weight percent of a cryoprotectant, wherein said cryoprotectant comprises an amino compound which is present in an amount that is equal to or greater than the amount of said oil;
A method of making a lyophilized composition which comprises formulating an oil-in-water emulsion comprising water, about 0.4 to 10 weight percent of an oil, about 0.2 to 4 weight percent of an emulsifier, and about 0.5 to 12.5 weight percent of a cryoprotectant, wherein the cryoprotectant comprises an amino compound and is present in an amount such that the weight ratio of the amino compound to the oil is between about 1/1 and 15/1 and the emulsion has a mean droplet size of between about 0.05 and 0.5 .mu.m;
A method of making a lyophilized composition which comprises formulating an oil-in-water emulsion comprising water, about 0.6 to 8 weight percent of an oil, about 0.25 to 2.5 weight percent of an emulsifier, about 0.25 to 2.5 percent by weight of a co-emulsifier, and about 1 to 10 weight percent of a cryoprotectant, wherein the cryoprotectant comprises an amino compound and is present in an amount such that the weight ratio of the amino compound to the oil is above about 1/1 and less than about 15/1 and the emulsion has a mean droplet size of between about 0.1 and 0.3 .mu.m;
Dependencies are inferred from the claim text.