Process for preparing trifluoromethylanilines
OwnerWolfgang Appel, Gunter Siegemundinventors
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Abstract
A process for preparing trifluoromethylanilines of the formula (I), ##STR1## in which R.sup.1 and R.sup.2, independently of each other, are hydrogen, halogen, (C.sub.1 -C.sub.4) alkyl, hydroxyl, alkoxy, alkylthio, carboxyl, or a nitro or cyano group, by reacting compounds of the formula (II) ##STR2## in which X.sub.1, X.sub.2 and X.sub.3 are in each case, identically or differently, halogen atoms, a is 0 or 1, Y is fluorine, chlorine or bromine, and R.sup.1 and R.sup.2 have the defined meaning, with anhydrous hydrofluoric acid, and converting the resulting aniline hydrofluorides with a base into the free amines.
Claims14
A process for preparing trifluoromethylanilines of the formula (I), ##STR5## in which R.sup.1 and R.sup.2, independently of each other, are hydrogen, halogen, (C.sub.1 -C.sub.4)alkyl, hydroxyl, alkoxy, alkylthio, carboxyl, or a nitro or cyano group, wherein compounds of the formula (II) ##STR6## in which X.sub.1, X.sub.2 and X.sub.3 are in each case, identically or differently, halogen atoms,
- a is 0 or 1,
- Y is fluorine, chlorine or bromine, and
- R.sup.1 and R.sup.2 have the defined meaning, are reacted with anhydrous hydrofluoric acid and the resulting aniline hydrofluorides are converted with a base into the free amine.
A process for the preparation of trifluoromethylaniline of the formula (I) ##STR7## in which R.sup.1 and R.sup.2, independently of each other, are hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, hydroxy, alkoxy, alkylthio, carboxyl, or a nitro or cyano group, comprising the steps of:
- reacting a compound of the formula II ##STR8## in which X.sub.1, X.sub.2, and X.sub.3 are in each case identically or differently, halogen atoms,
- a is 0 or 1, and
- Y is fluorine, chlorine, or bromine, with anhydrous hydrofluoric acid in an anhydrous environment to form aniline hydrofluoride,
- removing the hydrofluoric acid, and
- converting the aniline hydrofluoride with a base to a free amine.
Dependencies are inferred from the claim text.