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US 5,470,997 AGranted
Amphetamine derivatives and protein and polypeptide amphetamine derivative conjugates and labels
AssigneeBiosite Diagnostics, Inc.
InventorsKenneth F. Buechler, Joseph B. Noar, Si S. Moi
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Abstract
The present invention is directed to novel amphetamine derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to amphetamine and amphetamine metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.
Claims2
A compound of the formula:
- ##STR13## where R is --H, --CH.sub.3 where R' is an ortho, meta or para linking group consisting of one of the following;
- ##STR14## Where A is a linking group of from 1 to 20 carbons and from 0 to 10 heterocarbons (NH, O, S), either branched or straight chain.
Compounds of the formula:
- ##STR15## where R is --H, --CH.sub.3 where R' is a meta or para linking group consisting of one of the following;
- ##STR16##
Dependencies are inferred from the claim text.