Maspin, a serpin with tumor suppresing activity
AssigneeDana-Farber Cancer Institute, Inc.
InventorsRuth Sager, Anthony Anisowicz, Zhiqiang Zou
Life of this patent
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Abstract
An isolated DNA encoding a polypeptide substantially identical to maspin (SEQ ID NO:1); a substantially purified preparation of maspin; an antibody specific for maspin; and use of such DNAs and antibodies in diagnostic, screening, and therapeutic methods.
Claims17
A single- or double-stranded isolated DNA encoding a polypeptide having at least 90% sequence identity to maspin (SEQ ID NO:2) wherein said DNA hybridizes under stringent conditions with DNA sequence of SEQ ID NO:1, or the complement of said single stranded DNA.
Isolated genomic DNA encoding a polypeptide having at least 90% sequence identity to maspin (SEQ ID NO:2).
A single- or double-stranded isolated cDNA encoding a polypeptide having at least 90% sequence identity to maspin (SEQ ID NO:2).
An isolated DNA at least 30 nucleotides in length, comprising (a) a strand which hybridizes under stringent conditions to a DNA having the coding sequence of SEQ ID NO:1, (b) the complement thereof, or (c) a double stranded DNA comprising both (a) and (b).
An isolated DNA at least 40 nucleotides in length, comprising (a) a strand which hybridizes under stringent conditions to a DNA having the coding sequence of SEQ ID NO:1, (b) the complement thereof, or (c) a double stranded DNA comprising both (a) and (b).
An isolated DNA consisting of (a) a fragment of at least 30 nucleotides in length of the coding region of SEQ ID NO:
- 1, or (b) the complement thereof.
A single- or double-stranded isolated DNA encoding maspin (SEQ ID NO:2), or the complement of said single-stranded DNA.
A purified preparation of maspin (SEQ ID NO:2).
A hybrid polypeptide comprising (1) maspin (SEQ ID NO:2), covalently attached to (2) a second polypeptide.
Dependencies are inferred from the claim text.