Catalyzed sucrose-6-ester process
AssigneeMcNeil-PPC, Inc.
InventorsGeorge H. Sankey, Nicholas M. Vernon, Robert E. Wingard, Jr.
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Abstract
Sucrose is mono-acylated in the 6-position by reacting sucrose with a carboxylic acid anhydride such as acetic or benzoic anhydride in a reaction mixture containing a polar aprotic solvent and a catalytic quantity of a 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl)distannoxane, for a period of time and at a temperature sufficient to produce a sucrose-6-ester.
Claims40
A process which comprises reacting sucrose with a carboxylic acid anhydride in a reaction mixture consisting essentially of a first solvent comprising a polar aprotic solvent and a catalytic quantity of a 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl)distannoxane, for a period of time within the range of from about 1/4 hour to about 3 hours and at a temperature within the range of from about 0.degree. C. to about 60.degree. C., said time and temperature being sufficient to produce a sucrose-6-ester.
A process which comprises:
- (1) preparing a solution of sucrose and a 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl)distannoxane in a polar aprotic solvent to form a first reaction mixture;
- and
- (2) adding a carboxylic acid anhydride to said first reaction mixture to form a second reaction mixture and maintaining said second reaction mixture at a temperature and for a period of time sufficient to produce a sucrose-6-ester.
A process which comprises:
- (1) preparing a first reaction mixture comprising sucrose, a polar aprotic solvent, a second solvent capable of removing water by codistillation, and a 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl)distannoxane;
- (2) subjecting said first reaction mixture to codistillation to remove water, to form thereby a second reaction mixture;
- and
- (3) adding a carboxylic acid anhydride to said second reaction mixture to form a third reaction mixture and maintaining said third reaction mixture at a temperature and for a period of time sufficient to produce a sucrose-6-ester.
Dependencies are inferred from the claim text.