Antibodies for mevalonic acid and methods for immunological determination of mevalonic acid by using them
AssigneeOno Pharmaceutical Co., Ltd.
InventorsAkio Hayashi, Makoto Hiramatsu, Nobuyuki Hamanaka
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Abstract
Polyclonal and monoclonal antibodies are obtained specific to mevalonic acid, having low cross-reactivity with mevalonic acid analogues, such as glutaric acid, 3-methylglutaric acid and 3-hydroxy-3-methylglutaric acid. The antibodies may be used for determination of mevalonic acid providing an immunoassay excellent in sensitivity, specificity and reproducibility.
Claims10
An antibody specifically binds to mevalonic acid which is obtained by using, as antigen, a conjugate of protein selected from the group consisting of albumin, globulin, thyroglobulin, hemocyanin, edestin, and polylysine and a mevalonic acid derivative selected from the group consisting of the formula:
- ##STR3##
Dependencies are inferred from the claim text.