Human .beta..sub.2 integrin .alpha. subunit
AssigneeICOS Corporation
InventorsW. Michael Gallatin, Monica Van der Vieren
Life of this patent
Estimating the term…
Abstract
DNA encoding a novel human .beta..sub.2 integrin .alpha. subunit polypeptide, designated .alpha..sub.d, is disclosed along with methods and materials for production of the same by recombinant procedures. Binding molecules specific for .alpha..sub.d are also disclosed as useful for modulating the biological activities of .alpha..sub.d. DNA from other species which show homology to human .alpha..sub.d encoding sequences are also disclosed.
Claims5
A purified and isolated .alpha..sub.d extracellular domain polypeptide fragment consisting of about amino acid 17 to about amino acid 1108 of the human .alpha..sub.d amine acid sequence set out in SEQ IN NO:
- 2.l
A purified and isolated .alpha..sub.d I domain polypeptide fragment consisting of about amine acid 145 to about amino acid of the human .alpha..sub.d amine acid sequence set out in SEQ ID NO:
- 2.
A fusion protein comprising an .alpha..sub.d extracellular domain polypeptide fragment and immunoglobulin constant domain sequences, said .alpha..sub.d extracellular domain polypeptide fragment consisting of about amino acid 17 to about amino acid 1108 of SEQ ID NO:
- 2.
A purified and isolated .alpha..sub.d I domain polypeptide fragment consisting of about amino acid 150 to about amino acid 352 of the human .alpha..sub.d amino acid sequence set out in SEQ ID NO:
- 2.
A purified and isolated .alpha..sub.d polypeptide consisting of the amino acid sequence set out in SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.