Peptides for antagonizing the effects of amyloid .beta.protein
AssigneeCity of Hope
InventorEugene Roberts
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Abstract
Three non-amnestic and non-memory enhancing peptides, Asp Phe Phe Val Gly (SEQ ID NO: 1), Gln Phe Val Gly (SEQ ID NO: 2), and Ala Ile Phe Thr (SEQ ID NO: 3), that block the effects of .beta.-(12-28), a peptide homologous to amyloid .beta. protein (A.beta.) are disclosed. This invention relates to amelioration of amnesia and other neurotoxicitiy in Alzheimer disease (AD) caused by deposition of A.beta. and, therefore, relates to attenuation of the disease process and consequential improvement of the quality of life for individuals suffering from AD.
Claims4
A peptide having the sequence of SEQ ID NO:
- 1, SEQ ID NO:
- 2 or SEQ ID NO:
- 3.
A peptide ester having the structure Formula I.
A peptide amide having the structure Formula II.
Dependencies are inferred from the claim text.