Method for making amino acid glycosides and glycopeptides
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorRobin L. Polt
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Abstract
A compound of the formula ##STR1## is disclosed. X is selected from the group consisting of aryl, alkyl, imidate ester, imino ester, amidine, azide, isocyanate, and dithiocarbonate. R' is a group selected from the group consisting of groups containing a hydroxyl moiety, groups containing a protected hydroxyl moiety, and groups containing an O-linked sugar. G is a carbon chain of 0-10 carbons and R is not a methyl group and is a group capable of removal under conditions compatible with glycopeptide synthesis. In a preferred form the compound, R is selected from the group consisting of benzylic or allyl groups and X is CPh.sub.2. A method of forming a glycocide from the compound is also disclosed.
Claims3
A compound of the formula ##STR4## wherein X is an imino-bonded moiety selected from the group consisting of an imine, a Schiff's base, and an imidate ester;
- wherein G is a carbon chain of 0-10 carbons;
- wherein R is selected from the group consisting of phenyl and diphenyl groups;
- wherein R' is selected from the group consisting of groups containing a hydroxyl moiety, groups containing a protected hydroxyl moiety, and groups containing an O-linked sugar;
- and
- wherein R" is an amino acid chain having no more than thirteen amino acids.
Dependencies are inferred from the claim text.