Vasopressin and vasotocin derivatives
AssigneeSchering Corporation
InventorsFalk Fahrenholz, Walter Elger, Marianne Fahnrich, Kryzsztof Chwalisz
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Abstract
This invention relates to new vasopressin and vasotocin derivatives of general formula I ##STR1## in which A stands for the radical Mca (=3-mercapto-3,3-cyclpentamethylenepropionyl radical) or for the radical Mpa (=3-mercaptopropionyl radical), B stands for the amino acid radicals D-Tyr, D-Tyr(Et), D-Phe, Tyr(OMe), D-lle, D-Trp, or the radical of a hydrophobic D-amino acid, and C stands for phenylalanine (Phe; vasopressin derivatives) or isoleucine (lle; vasotocin derivatives). They have a high activity toward the oxytocin and the V-vasopressin receptors and can be used for the production of pharmaceutical agents.
Claims11
A vasopressin or vasotocin derivative of formula I ##STR17## wherein A is a 3-mercapto-3,3-cyclopentamethylene-propionyl radical (Mca) or a 3-mercapto-propionyl radical (Mpa),
- B is an amino acid radical D-Tyr, D-Tyr(Et), D-Phe, Tyr(OMe), D-lle, D-Trp or a radical of a hydrophobic D-amino acid, and
- C is Phe (vasopressin derivative) or lie (vasotocin derivative), with the proviso that B is not D-Phe when C is Phe.
A vasopressin or vasotocin derivative of formula I, which is ##STR18##
Dependencies are inferred from the claim text.