Diabetes prevention and treatment using gamma-pyrones
AssigneeUniversity Technologies International Inc.
InventorJi-Won Yoon
Life of this patent
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Abstract
This invention provides a method for preventing and/or treating diabetes in a mammal in need thereof comprising administering to the mammal an effective amount of at least one compound of the formula I: ##STR1## The invention also provides methods for preventing and/or treating diabetes comprising administering an effective amount of at least one compound of the formula I previously set forth and Orthosiphon Arestatus.
Claims9
A method for preventing type II diabetes in a mammal susceptible to developing said diabetes comprising administering to said mammal an effective amount of at least one compound of the formula I:
- ##STR3## wherein R.sub.1, R.sub.2 and R.sub.3 are independently selected from the group consisting of H, an alkyl of from 1 to 8 carbon atoms, an alkyl-o-alkyl of from 2 to 8 carbon atoms, a haloalkyl of from 1 to 8 carbon atoms and 1 to 3 halogen atoms, an alkenyl of from 2 to 8 carbon atoms with one site of unsaturation, ketones of from 2 to 8 carbon atoms, aldehydes of from 1 to 8 carbon atoms, and any of the above compounds which are alcohol-substituted;
- and R.sub.4 is either H or --COR.sub.5, wherein R.sub.5 is an alkyl of from 1 to 5 carbon atoms;
- or a salt thereof.
A method for the treatment of type I diabetes in a mammal exhibiting characteristics of said diabetes comprising administering to said mammal an effective amount of at least one compound of the formula I:
- ##STR4## wherein R.sub.1, R.sub.2 and R.sub.3 are selected from the group consisting of H, an alkyl group of from 1 to 8 carbon atoms, an alkyl-o-alkyl from 2 to 8 carbon atoms, a haloalkyl of from 1 to 8 carbon atoms and 1 to 3 halogen atoms, an alkenyl of from 2 to 8 carbon atoms with one site of unsaturation, ketones of from 2 to 8 carbon atoms, aldehydes of from 1 to 8 carbon atoms, and any of the above compounds which are alcohol-substituted;
- and R.sub.4 is either H or --COR.sub.5, wherein R.sub.5 is an alkyl of from 1 to 5 carbon atoms;
- or a salt thereof.
A method for preventing or treating any diabetes in a mammal in need thereof comprising:
- a) administering to said mammal an effective amount of at least one compound of the formula I:
- ##STR5## wherein R.sub.1, R.sub.2 and R.sub.3 are selected from the group consisting of H, an alkyl group of from 1 to 8 carbon atoms, an alkyl-o-alkyl from 2 to 8 carbon atoms, a haloalkyl of from 1 to 8 carbon atoms and 1 to 3 halogen atoms, an alkenyl of from 2 to 8 carbon atoms with one site of unsaturation, ketones of from 2 to 8 carbon atoms, aldehydes of from 1 to 8 carbon atoms, and any of the above compounds which are alcohol-substituted;
- and R.sub.4 is either H or --COR.sub.5, wherein R.sub.5 is an alkyl of from 1 to 5 carbon atoms;
- or a salt thereof;
- and
- b) administering Orthosiphon Aristatus.
Dependencies are inferred from the claim text.