Therapeutic compositions based on 1,2-dithiole-3-thione derivatives

Compounds of formula ##STR33## in which R.sub.1 and R.sub.2 are chosen, independently of one another, from hydrogen, a halogen;

• a nitro group, a nitroso group, a thiocyano group, a C.sub.1 -C.sub.6 alkyl group, a C.sub.2 -C.sub.6 alkenyl group, an aryl group, an aryl(C.sub.1 -C.sub.6 alkyl) group, an aryl(C.sub.2 -C.sub.6 alkenyl) group, a carboxyl group, a (C.sub.1 -C.sub.6 alkyl)carbonyl group, an arylcarbonyl group, a (C.sub.1 -C.sub.6 alkoxy)carbonyl group, a (C.sub.1 -C.sub.6 alkoxy)carbonyl(C.sub.1 -C.sub.6 alkyl) group, a C.sub.1 -C.sub.6 alkoxy group, a trifluoromethyl group, an amino group, a di(C.sub.1 -C.sub.6 alkyl)-amino(C.sub.1 -C.sub.6 alkyl) group, an acylamino group of formula --NHCOC.sub.n H.sub.2n+1 with n from 0 to 6, a group --NH--CSC.sub.n H.sub.2n+1 with n from 0 to 6, a terpenyl group, a cyano group, a C.sub.2 -C.sub.6 alkynyl group, a C.sub.2 -C.sub.6 alkynyl group substituted with a C.sub.1 -C.sub.6 alkyl or an aryl group, a hydroxy(C.sub.1 -C.sub.6 alkyl) group, a (C.sub.1 -C.sub.6 acyl)-oxy(C.sub.1 -C.sub.6 alkyl) group, a (C.sub.1 -C.sub.6 alkyl)thio group and an arylthio group,
• or alternatively R.sub.1 and R.sub.2 together form a mono- or polycyclic C.sub.2 -C.sub.20 alkylene group optionally comprising one or more hetero atoms, with the exception of the 2,2-dimethyltrimethylene group, or a C.sub.3 -C.sub.12 cycloalkylene group;
• and
• R'.sub.3 is chosen from a C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.6 alkyl group substituted with one or more groups chosen from hydroxyl, amino, chloro and C.sub.1 -C.sub.4 alkoxy groups and an aryl(C.sub.1 -C.sub.6 alkyl) group.

Compounds of formula ##STR34## in which R.sub.1 and R.sub.2 are chosen, independently of one another, from hydrogen, a halogen, a nitro group, a nitroso group, a thiocyano group, a C.sub.1 -C.sub.6 alkyl group, a C.sub.2 -C.sub.6 alkenyl group, an aryl group, an aryl(C.sub.1 -C.sub.6 alkyl) group, an aryl(C.sub.2 -C.sub.6 alkenyl) group, a carboxyl group, a (C.sub.1 -C.sub.6 alkyl)carbonyl group, an arylcarbonyl group, a (C.sub.1 -C.sub.6 alkoxy)carbonyl group, a (C.sub.1 -C.sub.6 alkoxy)carbonyl(C.sub.1 -C.sub.6 alkyl) group, a C.sub.1 -C.sub.6 alkoxy group, a trifluoromethyl group, an amino group, a di(C.sub.1 -C.sub.6 alkyl)-amino(C.sub.1 -C.sub.6 alkyl) group, an acylamino group of formula --NHCOC.sub.n H.sub.2n+1 with n from 0 to 6, a group --NH--CSC.sub.n H.sub.2n+1 with n from 0 to 6, a terpenyl group, a cyano group, a C.sub.2 -C.sub.6 alkynyl group, a C.sub.2 -C.sub.6 alkynyl group substituted with a C.sub.1 -C.sub.6 alkyl or an aryl group, a hydroxy(C.sub.1 -C.sub.6 alkyl) group, a (C.sub.1 -C.sub.6 acyl)-oxy(C.sub.1 -C.sub.6 alkyl) group, a (C.sub.1 -C.sub.6 alkyl)thio group and an arylthio group,

• or alternatively R.sub.1 and R.sub.2 together form a mono- or polycyclic C.sub.2 -C.sub.20 alkylene group optionally comprising one or more hetero atoms, with the exception of the 2,2-dimethyltrimethylene group, or a C.sub.3 -C.sub.12 cycloalkylene group;
• and
• R".sub.3 is chosen from a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.6 alkyl group substituted with one or more groups chosen from hydroxyl, amino, chloro and C.sub.1 -C.sub.4 alkoxy groups and an aryl(C.sub.1 -C.sub.6 alkyl) group.