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US 5,470,870 AGranted
NMDA antagonists
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsMichael G. Palfreyman, Ian A. McDonald, Francesco G. Salituro, Robert Schwarcz, Bruce M. Baron
Life of this patent
Estimating the term…
Abstract
The present invention is directed to a class of 4,6-disubstituted tryptophan derivatives, 4,6-disubstituted kynurenines, their use as NMDA antagonists and to pharmaceutical compositions containing these compounds.
Claims9
A method for antagonizing the effects of excitatory amino acids upon the NMDA receptor complex comprising administering to a patient in need thereof, an antagonistic amount of a compound of the formulae:
- ##STR7## or a (pharmaceutically acceptable salt thereof, in which X and Y are each independently represented by Cl, Br, F, CH.sub.3 or CH.sub.2 CH.sub.3 ;
- and Hal is a halogen atom.
Dependencies are inferred from the claim text.