Pharmaceutical composition
AssigneeEli Lilly and Company
InventorsMary K. McCauley, Kenneth P. Moder, Jeffrey L. Speakman
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Abstract
The present invention provides an odorless pharmaceutical composition of nizatidine. It also provides a novel form of nizatidine and a process for the preparation of this form.
Claims17
A pharmaceutical composition of nizatidine, in which the nizatidine has been heated in the presence of water to remove N-methyl-1-methylthio-2-nitroethyleneamine.
A pharmaceutical composition of nizatidine, in which the nizatidine is in a form which contains N,N'-bis[2-[[[2-[2-(dimethylamino)methyl]-4-thiazole]methyl]thio]ethyl]-2- nitro-1,1-ethenediamine and N,N'-dimethyl-2-nitro-1,1-ethenediamine, but not N-methyl-1-methylthio-2-nitroethyleneamine.
A process for preparing a form of nizatidine, which comprises heating nizatidine containing N-methyl-1-methylthio-2-nitroethyleneamine in the presence of water to remove said N-methyl-1-methylthio-2-nitroethyleneamine.
A form of nizatidine which contains N,N'-bis[2-[[[2-[2-(dimethylamino)methyl]-4-thiazole]methyl]thio]ethyl]-2- nitro-1,1-ethenediamine and N,N'-dimethyl-2-nitro-1,1-ethenediamine, but not N-methyl-1-methylthio-2-nitroethyleneamine.
Dependencies are inferred from the claim text.