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US 5,470,860 AGranted
1,4-dihydropyridines for use in the treatment of dermatoses
AssigneeByk Gulden Lomberg Chemische Fabrik GmbH
InventorKarl Sanders
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Abstract
The invention relates to the use of 1,4-dihydropyridines of the formula (I), in which the substituents and symbols are as defined in the description, for the preparation of medicaments for the treatment of dermatoses.
Claims16
A method of treating an amenable dermatosis by administering to a subject so afflicted an effective amount of a pharmaceutical composition comprising active component and pharmacologically-acceptable carrier therefor, wherein the active component is a 1,4-dihydropyridine of the formula ##STR1## in which R1 is 1-6C-alkyl or 1-4C-alkoxy-2-4C-alkyl,
- R2 is hydrogen, amino (NH.sub.2), 1-6C-alkyl or 1-4C-alkoxy-2-4C-alkyl,
- R3 is 1-6C-alkyl or 1-4C-alkoxy-2-4C-alkyl,
- R4 is phenyl substituted by R41 and R42,
- R41 is hydrogen, hydroxyl, halogen, nitro, cyano, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxy which is substituted completely or partially by fluorine, 1-4C-alkoxycarbonyl, 2-5C-acyl, amino, or mono- or di-1-4C-alkylamino,
- R42 is hydrogen, hydroxyl, halogen, nitro, cyano, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxy which is substituted completely or partially by fluorine, 1-4C-alkoxycarbonyl, 2-5C-acyl, amino, or mono- or di-1-4C-alkylamino,
- E1 is oxygen (O),
- E2 is straight-chain or branched 1-5C-alkylene, the group --(CH.sub.2).sub.m --E--(CH.sub.2).sub.n -- or the group --A1--O--A2--,
- E is vinylene (--CH.dbd.CH--) or ethynylene (--C.tbd.C--),
- m is 1 or 2,
- n is 1 or 2,
- A1 is 2-4C-alkylene,
- A2 is 2-4C-alkylene or 2C-alkyleneoxy-2C-alkylene,
- R5 and R6 together, including the nitrogen atom to which both are attached, are a radical of the formula Ia ##STR2## in which A is --CH.sub.2 --CH.sub.2 --C(R7)R8--CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CHR9--CH.sub.2 --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CHR10--,
- R7 is hydrogen (H) or aryl and
- R8 is aryl, or
- R7 and R8 together are diarylmethylene,
- R9 is diaryl-1-4C-alkyl, and
- R10 is aryl-1-4C-alkyl,
- wherein aryl is phenyl which is substituted by R11 and R12, and where R11 and R12 are identical or different and are hydrogen (H), 1-4C-alkyl, 1-4C-alkoxy, halogen, hydroxyl, trifluoromethyl or together are methylenedioxy,
- or a pharmacologically-acceptable salt thereof.
17 more elements
Dependencies are inferred from the claim text.