Carbocyclic nucleoside analogs useful as immunosuppressants
AssigneeMarion Merrell Dow Inc.
InventorsDavid R. Borcherding, Carl K. Edwards, III, Ronald E. Esser, Douglas L. Cole
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Abstract
This invention relates to a method of effecting immunosuppression in a patient in need thereof comprising administering an effective amount of a compound of the formula (1) ##STR1## wherein the hydroxy substituent on the cyclopentenyl ring is in the CIS configuration relative to the bicyclic substituent, Y.sub.3, Y.sub.7, Y.sub.8 and Y.sub.9 are each independently nitrogen or a CH group, Q is NH.sub.2, halogen or hydrogen, and Z is hydrogen, halogen, or NH.sub.2 ; or a pharmaceutically-acceptable salt thereof.
Claims24
A method of effecting immunosuppression in a patient in need thereof comprising administering to said patient an effective immunosuppressive amount of (1R,33)-Cis-1-(9-adenyl)-3-hydroxy-4-cyclopentene or pharmaceutically acceptable salt thereof.
A method of effecting immunosuppression in a patient in need thereof comprising administering to said patient an effective immunosuppressive amount of (1S,3R)-Cis-1-(9-adenyl)-3-hydroxy-4-cyclopentene or pharmaceutically-acceptable salt thereof.
A method of effecting immunosuppression in a patient need thereof comprising administering to said patient an effective immunosuppressive amount of (1R,3S)-Cis-1-[9-(8-azaadenyl)]-3-hydroxy-4-cyclopentene or pharmaceutically-acceptable salt thereof.
A method of effecting immunosuppression in a patient in need thereof comprising administering to said patient an effective immunosuppressive amount of (1R,3S)-Cis-1-[9-(2,6-diaminopurinyl)]-3-hydroxy-4-cyclopentene or pharmaceutically-acceptable salt thereof.
A pharmaceutical composition comprising an effective immunosuppressive amount of (1R,3S)-Cis-1-(9-adenyl)-3-hydroxy-4-cyclopentene or pharmaceutically-acceptable salt thereof, in admixture or otherwise in association with one or more pharmaceutically acceptable carriers or excipients.
A pharmaceutical composition comprising an effective immunosuppressive amount of (1S,3R)-Cis-1-(9-adenyl)-3-hydroxy-4-cyclopentene or pharmaceutically acceptable salt thereof, in admixture or otherwise in association with one or more pharmaceutically acceptable carriers or excipients.
A pharmaceutical composition comprising an effective immunosuppressive amount of (1R,3S)-Cis-1-[9-(8-azaadenyl)]-3-hydroxy-4-cyclopentene or pharmaceutically-acceptable salt thereof, in admixture or otherwise in association with one or more pharmaceutically acceptable carriers or excipients.
A pharmaceutical composition comprising an effective immunosuppressive amount of (1R,3S)-Cis-1-[9-(2,6-diaminopurinyl)]-3-hydroxy-4-cyclopentene or pharmaceutically-acceptable salt thereof, in admixture or otherwise in association with one or more pharmaceutically acceptable carriers or excipients.
Dependencies are inferred from the claim text.