Tetrahydropyrimidine derivatives
AssigneeAkzo Nobel N.V.
InventorRalf Plate
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Abstract
The invention is concerned with a tetrahydropyrimidine derivative having formula I ##STR1## wherein R.sub.1 is hydrogen; R.sub.2 is hydrogen, a lower alkyl group, or lower acyl; or R.sub.1 and R.sub.2 represent together a bond; R.sub.3 is hydrogen, a lower hydrocarbon group optionally substituted with halogen, CN, aryl, or COR.sub.7 ; R.sub.4 is hydrogen, a lower alk(en)yl group, or aryl; R.sub.5 is hydrogen, amino, lower alkyl substituted amino, or a lower alkyl group; and R.sub.6 is hydrogen or methyl; R.sub.7 is amino, lower alkyl substituted amino, or a lower alkyl group; or a pharmaceutically acceptable salt thereof. The compounds of this invention have muscarinic properties and can be used for the treatment of cognition disorders, and for the treatment of cholinergic deficiencies.
Claims12
A tetrahydropyrimidine derivative having formula I ##STR6## wherein R.sub.1 is hydrogen;
- R.sub.2 is selected from the group consisting of hydrogen, a lower alkyl group having 1 to 6 carbon atoms, and a lower acyl group derived from an aliphatic carboxylic acid having 2 to 6 carbon atoms;
- or R.sub.1 and R.sub.2 represent together a bond;
- R.sub.3 is selected from the group consisting of hydrogen, COR.sub.7 and a lower hydrocarbon group containing 1-18 carbon atoms and optionally substituted with halogen, CN, alkoxycarbonyl, phenyl or a phenyl group substituted with a substituent selected from the group consisting of OH, F, Cl, Br, CF.sub.3, lower alkyl and lower alkoxy;
- R.sub.4 is selected from the group consisting of hydrogen, a lower alkyl group, a lower alkenyl group having 1 to 6 carbon atoms, phenyl or a phenyl group substituted with a substituent selected from the group consisting of OH, F, CL, BR, CF.sub.3, lower alkyl and lower alkoxy;
- R.sub.5 is selected from the group consisting of hydrogen, amino, lower alkyl substituted amino, and a lower alkyl group;
- and
- R.sub.6 is hydrogen or methyl, provided that when R.sub.1 and R.sub.2 together represent a bond and R.sub.3, R.sub.4 and R.sub.5 are hydrogen, R.sub.6 is methyl;
- R.sub.7 is selected from the group consisting of amino, lower akyl-substituted amino, and a lower alkyl group;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.