Tetrahydroprotoberberine quaternary ammonium compounds useful in for treating arrhythmia
AssigneesChina Pharmaceutical University, Administrative Center of New Drug Research, The State Pharmaceutical Administration of China
InventorsSixun Peng, Dezai Dai, Zhenya Huang, Wenlong Huang, Youqun Wang, Can Zhang, Feng Yu
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Abstract
A tetrahydroprotoberberine quaternary ammonium compound represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R' and X are as defined in the specification. A method of preparing the compound is provided. The compounds can suppress arrhythmia and ventricular fibrillation, protect against myocardial ischemia, and can be conveniently orally administered.
Claims3
A method of treating arrhythmia comprising administering an effective anti-arrhythmia amount of a tetrahydroprotoberberine quaternary ammonium compound having the formula:
- ##STR20## wherein R.sub.1 and R.sub.2 are CH.sub.3 O--, or taken together with the adherent carbon atoms to form a ring represented by the structure ##STR21## X is I, Cl or Br;
- and R' is --CH.sub.3 when X is I, R' is --C.sub.2 H.sub.5, --CH.sub.2 CH.dbd.CH.sub.2, --CH.sub.2 COOC.sub.2 H.sub.5 ##STR22## when X is Br, and R' is ##STR23## to a patient in need thereof.
A compound which is 7-(4-chlorobenzyl)-5,8,13,13a-tetrahydroberberine chloride.
Dependencies are inferred from the claim text.