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US 5,470,847 AGranted
Ovulation control by regulating nitric oxide levels with arginine derivatives
AssigneeBoard of Regents, The University of Texas System
InventorsRobert E. Garfield, Chandrasekhar Yallampalli
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Abstract
Inhibition of ovulation in a female may be achieved by administering an arginine derivative which acts as a nitric oxide sythase inhibitor, alone or in combination with one or more of a progestin, an estrogen, and an LH-RH antagonist, thereby preventing conception.
Claims19
A method of contraception comprising:
- administering an inhibitor of nitric oxide production selected from the group consisting of N.sup.G -nitro-L-arginine methyl ester, N.sup.G -ethyl-L-arginine, N-iminoethyl-L-arginine, L-N.sup.G -methylarginine and N.sup.G -nitro-L-arginine to a female in an amount inhibiting ovulation.
A method of contraception comprising administering N.sup.G -nitro-L-arginine methyl ester to a female in an amount inhibiting ovulation.
A method of contraception comprising:
- administering an N.sup.G -substituted arginine or an N.sup.G,N.sup.G -disubstituted arginine having a nitro, amino, imino, iminoalkyl, lower alkyl, lower hydroxyalkyl or lower alkenyl substituent replacing a guanidino amino group hydrogen, in an amount inhibiting ovulation.
A method of contraception comprising:
- administering an inhibitor of nitric oxide production selected from the group consisting of N.sup.G -nitro-L-arginine methyl ester, N.sup.G -ethyl-L-arginine, N-iminoethyl-L-arginine, L-N.sup.G -methylarginine and N.sup.G -nitro-L-arginine to a female in an amount inhibiting ovulation;
- and
- administering a therapeutically effective amount of at least one of a progestational agent, an estrogen, an antigonadotropin or a GnRH antagonist.
Dependencies are inferred from the claim text.