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US 5,470,837 AGranted
5'-vinylhalo-aristeromycin/adenosine analogs and immunosuppressants
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsJeffrey A. Wolos, Niall S. Doherty, Esa T. Jarvi, James R. McCarthy
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Abstract
The present invention relates to a method of effecting immunosuppression in a patient in need thereof comprising administering to said patient an effective immunosuppressive amount of certain 5'-vinylhalo-aristeromycin/adenosine analogs.
Claims8
A method of effecting immunosuppression in a patient in need thereof comprising administering to said patient an effective immunosuppressive amount of a compound of the formula ##STR6## wherein V is oxy or methylene,
- X.sub.1 and X.sub.2 are each independently hydrogen or halogen with the proviso that at least one of X.sub.1 and X.sub.2 is always a halogen atom,
- A.sub.1 and A.sub.2 are each independently hydrogen, halogen,or hydroxy with the provisos that where A.sub.1 is hydroxy, A.sub.2 is hydrogen, and that where A.sub.2 is hydroxy, A.sub.1 is hydrogen,
- Y.sub.1 is nitrogen, a CH group, a CCl group, a CBr group or a CNH.sub.2 group,
- Y.sub.2 and Y.sub.3 are each independently nitrogen or a CH group,
- Q is NH.sub.2, NHOH, NHCH.sub.3, or hydrogen, and Z is hydrogen, halogen, or NH.sub.2.
2 more elements
Dependencies are inferred from the claim text.