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AssigneeFarmitalia Carlo Erba S.p.A.
InventorsLuigi Donno, Giuseppe Cassinelli
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A compound of formula (I): ##STR1## wherein: R.sub.1 is a hydroxy group or an amino group optionally substituted with a C.sub.1 -C.sub.4 alkyl or phenyl-(C.sub.1 -C.sub.4) alkyl group, R.sub.2 is hydrogen or a hydroxy group, R.sub.3 is hydrogen or chlorine, R.sub.4 is hydrogen or a hydroxy or amino group, R.sub.5 is hydrogen or a hydroxy group, and R.sub.6 is hydrogen or a hydroxy group, or a non-toxic acid addition salt thereof, is useful in the parenteral treatment of visceral leishmaniasis or malaria, and a synergistic composition comprising a compound of formula (I) or a non-toxic acid addition salt thereof and sodium stibogluconate is useful in the treatment of visceral leishmaniasis.
A method of treatment of visceral leishmaniasis which comprises administering parenterally to a subject suffering therefrom, paromomycin or a non-toxic acid addition salt thereof, and sodium stibogluconate, in a weight ratio of from 1:9 to 9:1.
A composition suitable for parenteral administration for the treatment of visceral leishmaniasis, which composition comprises paromomycin or a non-toxic acid addition salt thereof, sodium stibogluconate and a pharmaceutically acceptable diluent, the weight ratio of the paromomycin or salt thereof to the sodium stibogluconate being from 1:9 to 9:1.
Dependencies are inferred from the claim text.