Transfer factor and methods of use
AssigneeNational Jewish Center for Immunology and Respiratory Medicine
InventorsCharles H. Kirkpatrick, Stephen J. Rozzo
Life of this patent
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Abstract
The invention relates to substantially pure transfer factor with a specific activity of at least 5000 units per absorbance unit at 214 nm. The present invention also relates to a process for preparing the transfer factor from cell lysates. The present invention includes the use of substantially pure transfer factor with a specific activity of at least 5000 units per absorbance unit at 214 nm to treat infectious diseases.
Claims23
An isolated transfer factor with a specific activity of at least 5000 units of transfer factor activity per absorbance unit at 214 nm wherein a unit of transfer factor activity is defined as the amount of material that produces a half-maximal footpad swelling response in mice, and wherein the isolated transfer factor is capable of transferring delayed-type cell mediated immunity to a non-immune human or animal.
An isolated transfer factor with a molecular weight of between about 4500 and 5500 Daltons as determined by amino acid analysis, that migrates as a single peak on reverse phase high performance liquid chromatography, which has a specific activity of at least 5000 units of transfer factor activity per absorbance unit at 214 nm wherein a unit of transfer factor activity is defined as the amount of material that produces a half-maximal footpad swelling response in mice, and wherein the isolated transfer factor is capable of transferring delayed-type cell mediated immunity to a non-immune human or animal.
A method of treating a human or vertebrate animal with an infection caused by a microorganism selected from the group consisting of bacteria, fungi, protozoa and herpes virus comprising the step of administering to the human or vertebrate animal with the infection a therapeutically effective amount of an isolated transfer factor specific for the microorganism with a specific activity of at least 5000 units of transfer factor activity per absorbance unit at 214 nm wherein a unit of transfer factor activity is defined as the amount of material that produces a half-maximal footpad swelling response in mice, and wherein the isolated transfer factor is capable of transferring delayed-type cell mediated immunity to a non-immune human or animal
A method of preventing an infection in a human or vertebrate animal caused by a microorganism selected from the group consisting of bacteria, fungi, protozoa and herpes virus comprising the step of administering to the human or vertebrate animal a therapeutically effective amount of an isolated transfer factor specific for the microorganism with a specific activity of at least 5000 units of transfer factor activity per absorbance unit at 214 nm wherein a unit of transfer factor activity is defined as the amount of material that produces a half-maximal footpad swelling response in mice, and wherein the isolated transfer factor is capable of transferring delayed-type cell mediated immunity to a non-immune human or animal.
Dependencies are inferred from the claim text.