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US 5,470,828 AGranted
Peptide analogs of insulin-like growth factor II
AssigneeGropep Pty. Ltd.
InventorsFrancis J. Ballard, John C. Wallace, Julian R. E. Wells
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Abstract
The invention provides peptide analogues of insulin-like growth factor-1 (IGF-1) or factor-2 (IGF-2). The peptide analogues of IGF-1 have at least the glutamic acid residue at position 3 replaced by another amino acid. The peptide analogues of IGF-2 are replaced at position 5 or 6 with another amino acid.
Claims3
A peptide analog of human bovine, ovine, porcine or chicken insulin-like growth factor II (IGF-II) having the following modified N-terminal sequence:
- Thr-Leu-Cys-
- with the Cys residue shown being the amino acid residue at position 8 or 9 from the N-terminal of the native amino acid sequence of the IGF-II with the remainder of the IGF-II peptide analog sequence being an amino acid sequence of a human, bovine, ovine, porcine or chicken IGF-II beginning at the amino acid residue immediately following the Cys residue at position 8 or 9 from the N-terminal of the native IGF-II amino acid sequence.
Dependencies are inferred from the claim text.