Method to treat Kaposi's sarcoma
AssigneeThe Regents of the University of California
InventorsSteven A. Miles, Ronald H. Stevens, Otoniel M. Martinez, Tadamitsu Kishimoto, David J. Klashman
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Abstract
Substances or agents which diminish the level of IL-6 or its activity in Kaposi's sarcoma-derived cells are useful agents in the treatment of Kaposi's sarcoma. In particular, substances which inhibit the expression of the gene encoding IL-6 or its receptor, or which interfere with the activity of these substances, are useful in the treatment of this condition. In particular, antibodies immunoreactive with these proteins, oligomers which interfere with the production of these materials, or substances which interfere with the activity of other proteins, DNAs or RNAs that regulate the production and activity of IL-6 are thus useful.
Claims1
A method to intervene in the progress of Kaposi's sarcoma, which method comprises administering to a subject in need of such intervention an amount of IL-4 effective to decrease IL-6 function in Kaposi's sarcoma-involved cells.
Dependencies are inferred from the claim text.