Antibodies that bind to a ligand-induced binding site on GPIIIa
AssigneeThe Scripps Research Institute
InventorsAndrew L. Frelinger, III, Edward F. Plow, Mark H. Ginsberg
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Abstract
An antibody that immunoreacts with a ligand-induced binding site (LIBS) on GPIIIa, and particularly, a LIBS induced in a platelet-associated GPIIb-IIIa/fibrinogen complex is disclosed. Further disclosed are diagnostic systems and methods for assaying LIBS-containing platelets in a vascular fluid sample using the antibodies of the invention.
Claims7
A monoclonal antibody composition comprising antibody molecules, or fragments thereof, that are capable of specifically immunoreacting with a ligand-induced binding site on GPIIIa when GPIIIa-containing receptor is specifically bound to a GPIIb-IIIa-specific ligand, but do not immunoreact with either said GPIIIa-containing receptor or said ligand when either is in non-bound form.
A hybridoma that produces antibody molecules that specifically immunoreact with a ligand-induced binding site on GPIIIa when a GPIIIa-containing receptor is specifically bound to a GPIIb-IIIa-specific ligand, but do not immunoreact with either said GPIIIa-containing receptor or said ligand when either is in non-bound form.
Dependencies are inferred from the claim text.