Back to results
US 5,470,736 AGranted
Transdominant negative proto-oncogene
AssigneeThe Salk Institute for Biological Studies
InventorsInder M. Verma, Ronald M. Wisdom, Jong-Young J. Yen
Life of this patent
Estimating the term…
Abstract
The present invention provides polynucleotide and polypeptide sequences for a trans-repressing protein of the Fos proto-oncogene family, where the polypeptide is characterized by having a leucine zipper domain and forming a heterodimer with a Jun related protein. This heterodimer is capable of biding to an AP-1 site and suppressing transcriptional transactivation of a promoter containing the AP-1 site.
Claims20
An isolated polynucleotide encoding a trans-repressing FosB2 protein, wherein the protein is characterized by:
- (a) having a leucine zipper domain;
- and
- (b) forming a heterodimer with a Jun related protein, wherein the heterodimer is capable of:
- (i) binding to an AP-1 site;
- and
- (ii) suppressing transcriptional transactivation of a promoter containing the AP-1 site;
- and
- (c) having an amino acid sequence of Sequence ID No. 2, wherein amino acids 238-284 are deleted therefrom.
5 more elements
Dependencies are inferred from the claim text.