Recombinant herpesvirus of turkeys and live vector vaccines derived thereof
AssigneeAkzo Nobel N.V.
InventorsPaulus J. A. Sondermeijer, Johannes A. J. Claessens, Albert P. A. Mockett
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Abstract
The present invention is concerned with a recombinant Herpesvirus of Turkeys (HVT), containing a heterologous gene incorporated into an insertion region of the genome of HVT. The invention also relates to a vector vaccine comprising such a recombinant HVT which expresses a heterologous antigenic polypeptide and induces an adequate immune response on infection of an appropriate host animal.
Claims8
A vaccine comprising a recombinant herpesvirus of turkeys (HVT) comprising a heterologous nucleic acid sequence that encodes an antigen of an avian pathogen, said nucleic acid sequence being introduced in an insertion region of the HVT genome from the end of ORF-1 through ORF-5 located within a DNA fragment of the HVT genome having a restriction enzyme map defined in FIG. 1.
A vaccine comprising a recombinant herpesvirus of turkeys (HVT) that contains a heterologous nucleic acid sequence that encodes an antigen of an avian pathogen, said nucleic acid sequence being introduced in an insertion region of the HVT genome between nucleotide positions 82 and 4504 as defined in SEQ ID NO:1.
Dependencies are inferred from the claim text.