Formation of and dehydration of hydroxylated diphenyl acetylenes using Pseudomonas ATCC 55272
AssigneeBio-Technical Resources
InventorAlan D. Grund
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Abstract
Cis-dihydrodiol compounds of the formula ##STR1## where n is 0 or 1 (preferably 0) are produced by the microbial oxidation of a diphenylaceylene compound of the formula ##STR2## using a mutant of a Pseudomonas bacteria at 25.degree. to 35.degree. C. and pH 6-8. The cis-dihydrodiol compound is in turn treated with an aqueous solution of a base to produce a corresponding 3-hydroxydiphenylacetylene compound or with an aqueous solution of an acid to produce a corresponding 2-hydroxyacetylene compound. The mutant strain is preferably Pseudomonas ATCC 55272.
Claims1
A process for the production of a product compound of the formula ##STR9## , comprising growing Pseudomonas ATCC 55272 in a growth medium at 25.degree. C. to 35.degree. C. and at a pH in the range of 6 to 8, supplying a compound of the formula ##STR10## to the growing strain to produce the product compound of formula ##STR11## , and recovering the product compound from the medium.
Dependencies are inferred from the claim text.