Production of human somatomedin C
AssigneeBiogen, Inc.
InventorsGary N. Buell, Nageswararao Movva
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Abstract
A process for selecting DNA sequences that are optimal for the production of polypeptides in hosts transformed with those DNA sequences. These DNA sequences, which code for a variety of human and animal proteins, permit the high level expression of those products in host cells. In the preferred embodiment of this invention, DNA sequences optimal for the production of human somatomedin C are selected and employed to express that growth enhancing factor.
Claims9
A process for producing an SMC polypeptide characterized by the step of culturing a bacterial or yeast host transformed by a vector selected from the group consisting of pLC24muSMC 1 through pLC24muSMC 10.
A DNA sequence selected from the group consisting of the SMC coding sequences of pLC24muSMC 1 through pLC24muSMC 10.
A vector having a DNA sequence selected from the group consisting of the SMC coding sequences of pLC24muSMC 1 through pLC24muSMC 10.
Dependencies are inferred from the claim text.