Modified OmpA signal sequence for enhanced secretion of polypeptides
OwnerShi-Yuan Meng, Charles F. Morris +1inventors
InventorsShi-Yuan Meng, Charles F. Morris, Larry B. Tsai
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Abstract
A signal peptide sequence and nucleic acids encoding this sequence which are useful for improving the secretion efficiency of NGF polypeptides are provided. Also provided is a method for preparing Met-less NGF polypeptides.
Claims27
A nucleic acid comprising the sequence of SEQ ID NO:2.
A nucleic acid comprising a sequence selected from the group consisting of:
- SEQ ID NO:3;
- SEQ ID NO:18;
- SEQ ID NO:19;
- SEQ ID NO:20;
- and SEQ ID NO:21.
A nucleic acid comprising the sequence of SEQ ID NO:3.
A nucleic acid comprising the sequence of SEQ ID NO:18.
A nucleic acid comprising the sequence of SEQ ID NO:19.
A nucleic acid comprising the sequence of SEQ ID NO:20.
A nucleic acid comprising the sequence of SEQ ID NO:21.
The vector pCFM1656/BDNFopt3.
The vector pCFM1656/NT-3opt3.
Dependencies are inferred from the claim text.