Equine herpesvirus type 1 glycoprotein D nucleic acids
AssigneeResearch Corporation Technologies, Inc.
InventorDennis J. O'3 Callaghan
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Abstract
The present invention is directed to a gene encoding an envelope glycoprotein of equine herpesvirus type 1 (EHV-1), the glycoprotein D (gD) gene, its gene product and antibodies directed against gD polypeptides. The envelope glycoproteins of herpesvirus are major targets of the immune response to herpesviral infection. Hence, an important aspect of this invention is directed towards a vaccine against EHV-1 and treatment of EHV-1 infection by anti-EHV-gD antibodies or antisera.
Claims15
An isolated nucleic acid having a nucleotide sequence that encodes the equine herpesvirus type 1 glycoprotein D polypeptide having the amino acid sequence of FIG. 2.
An isolated nucleic acid having a nucleotide sequence that encodes amino acids, 51-422 of the equine herpesvirus type 1 glycoprotein D polypeptide of FIG. 2.
An isolated nucleic acid having a nucleotide sequence that encodes amino acids 57-422 of the equine herpesvirus type 1 glycoprotein D polypeptide of FIG. 2.
An isolated nucleic acid having a nucleotide sequence that encodes amino acids 58-422 of the equine herpesvirus type 1 glycoprotein D polypeptide of FIG. 2.
An isolated nucleic acid having a nucleotide sequence that encodes amino acids 77-422 of the equine herpesvirus type 1 glycoprotein D polypeptide of FIG. 2.
A replicable expression vector comprising a nucleic acid which encodes a polypeptide having the amino acid sequence shown in FIG. 2.
A microorganism or cell transformed by a nucleic acid which encodes a polypeptide having the amino acid sequence shown in FIG. 2.
Dependencies are inferred from the claim text.