Method for determining favorable prognosis in an HIV positive subject using HLA-DR.sup.+ /CD38.sup.- CD8.sup.bright cells
AssigneeThe Regents of the University of California
InventorsJanis V. Giorgi, Lance Hultin
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Abstract
The subject invention involves an approach to determining the favorable prognosis of a subject infected with HIV. Specifically, the discovery involves the importance of the elevated presence of MHC class II antigen.sup.+ /CD38.sup.- /CD8.sup.bright cells for the prognosis of favorable outcome in HIV-infected subjects. In one example the MHC class II antigen may be HLA-DR.
Claims29
A method for determining a favorable prognosis in an HIV positive subject which comprises quantitatively detecting an elevated level of HLA-DR.sup.+ /CD38.sup.- /CD8.sup.bright cells thereby determining a favorable prognosis in the HIV positive subject.
A method of diagnosing a stable disease condition associated with HIV in a human comprising:
- (a) obtaining a blood sample from the human;
- (b) testing the sample by determining at least one measure of an activated CD8.sup.bright cell population having HLA-DR.sup.+ /CD38.sup.- /CD8.sup.bright cells;
- (c) applying a relationship between the HLA-DR.sup.+ /CD38.sup.- /CD8.sup.bright cell population in relation to an activated CD8.sup.bright cell population as a diagnostic evaluation of a favorable prognosis of the disease condition;
- and
- (d) presenting such relationship thereby diagnosing a stable disease condition associated with HIV in the human.
A method for monitoring the course of disease in an HIV positive subject which comprises quantitatively determining in a first cell sample from the subject the presence of HLA-DR.sup.+ /CD38.sup.- /CD8.sup.bright cells and comparing the amount so determined with the amount present in a second sample from the subject, such samples being taken at different points in time, a difference in the amounts determined being indicative of the course of disease.
A method of diagnosing a disease condition related to HIV in a human comprising:
- (a) obtaining a blood sample from the human,
- (b) determining from the sample at least one measure of an activated CD8.sup.bright cell population having HLA-DR.sup.+ /CD38.sup.- /CD8.sup.bright cells,
- (c) presenting such measure, and
- (d) applying the measure of the HLA-DR.sup.+ /CD38.sup.- /CD8.sup.bright cell population selectively as at least one of a diagnostic evaluation of a favorable prognosis of a disease condition, a stable disease condition or condition of inhibition of HIV replication.
A method of diagnosing a disease condition related to HIV in a human comprising:
- (a) obtaining a blood sample from the human,
- (b) determining from the sample at least one measure of an activated CD8.sup.bright cell population having HLA-DR.sup.+ /CD38.sup.- /CD8.sup.bright cells in the sample,
- (c) applying a relationship between the HLA-DR.sup.+ /CD38.sup.+ /CD8.sup.bright cell population in relation to a CD8.sup.+ lymphocyte population as a diagnostic evaluation of at least one of a favorable prognosis of the disease condition, a stable condition or suppressor of HIV replication;
- and
- (d) presenting such relationship.
A method of diagnosing a disease condition related to HIV infection in a human comprising:
- (a) obtaining a blood sample from the human,
- (b) determining from the sample at least one measure of a lymphocyte population having a HLA-DR.sup.+ /CD38.sup.- /CD8.sup.bright cell,
- (c) applying a relationship between the HLA-DR.sup.+ /CD38.sup.- /CD8.sup.bright cell population and the lymphocyte population as at least one of a diagnostic evaluation of the prognosis of a favorable disease condition, a stable condition or an HIV suppression condition, and
- (d) presenting such relationship.
Dependencies are inferred from the claim text.